In Prevention of organ rejection in transplant patients Alagraf 0.5 Capsule belongs to a group of medicines known as immunosuppressants. Organ rejection happens when your immune system treats the new organ as an invader and attacks it. This medicine weakens your immune response (which usually fights infection) and reduces the chance of your body attacking the transplanted organ. It is used in combination with other medicines to make it much more likely that your transplant operation will be successful. You should continue taking the medicine and should not stop it until your doctor says so.
Take this medicine in the dose and duration as advised by your doctor. Alagraf 0.5 Capsule may be taken with or without food.
- Alcohol : CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Alagraf 0.5 Capsule. Please consult your doctor. | - Pregnancy : CONSULT YOUR DOCTOR
Alagraf 0.5 Capsule is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks. | - Breast feeding : CONSULT YOUR DOCTOR
Alagraf 0.5 Capsule may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor. | - Driving : CONSULT YOUR DOCTOR
It is not known whether Alagraf 0.5 Capsule alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor. | - Kidney : CAUTION
Alagraf 0.5 Capsule should be used with caution in patients with kidney disease. Dose adjustment may be needed. | - Liver : CAUTION
Alagraf 0.5 Capsule should be used with caution in patients with severe liver disease. Dose adjustment may be needed.
If you miss a dose of Alagraf 0.5 Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Which vaccines should not be taken while taking Alagraf 0.5 Capsule?::: You should avoid taking any live vaccines (vaccines that use pathogens that are still alive, but are attenuated, that is, weakened) while taking Alagraf 0.5 Capsule. These may include vaccinations for measles, mumps, rubella, BCG (TB vaccine), yellow fever, chicken pox and typhoid. You should also avoid taking polio drops (by mouth) or flu vaccine (through nose).| Who should not take Alagraf 0.5 Capsule?::: Patients who are allergic to it or have a weak immune system, high blood pressure, and kidney failure should avoid Alagraf 0.5 Capsule. This medicine should also be avoided in pregnant or breastfeeding women, and in people who plan to receive any live vaccines (e.g. MMR vaccine).| What should I tell my doctor before taking Alagraf 0.5 Capsule?::: Inform your doctor if you are pregnant, have allergies, long-term infection, high blood sugar, or high blood pressure. You should also inform your doctor if you have high blood potassium levels or a weakened immune system. Tell your doctor if you have a history of any medication, have recently received, or are scheduled to receive a live vaccine. | What should I be aware of before I start taking Alagraf 0.5 Capsule?::: This medicine suppresses the immune system and hence there is always an increased risk of infection. Moreover, in some cases, Alagraf 0.5 Capsule can increase the risk of some kind of cancer like skin and lymph gland cancer (lymphoma). It can lower the ability of your immune system to fight infections. Consult your doctor before you start taking this medication and in case you notice any symptoms of infections like fever, sweats or chills, cough or flu-like symptoms, muscle aches, warm, red, or painful areas on your skin. | Does Alagraf 0.5 Capsule have an abuse potential?::: No, Alagraf 0.5 Capsule does not have abuse potential and thus, is not a controlled substance. Controlled substances have potential for abuse so they need permission from authorities and doctors for use.
Alagraf 0.5 Capsule is an immunosuppressant. It works by suppressing your body?s immune response following the transplant of an organ (e.g., liver, kidney, heart). This helps your body to accept the new organ as if it were your own.
-Domperidone (Oral Route): Life-threatening
Do not consume Tacrolimus with Domperidone. Concomitant use may affect heart rhythm and can be fatal.
| -Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route): Life-threatening
Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) should not be used while undergoing treatment with Tacrolimus or for up to 6 months after stopping Tacrolimus. Concurrent use may cause fatal infections.
| -Natalizumab (Injection Route): Life-threatening
Do not consume Natalizumab with Tacrolimus. Long-term concurrent use may increase the risk of certain brain infections.
| -Aceclofenac (Oral Route): Severe
If concurrent use is essential, your doctor may monitor your tacrolimus levels, potassium levels and kidney function closely. They may adjust the doses as per the observations. Concurrent use may increase the risk of serious damage to the kidneys.
| -Aceclofenac (Injection Route): Severe
If concurrent use is essential, your doctor may monitor your tacrolimus levels, potassium levels and kidney function closely. They may adjust the doses as per the observations. Concurrent use may increase the risk of serious damage to the kidneys.