Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. ADMINE 400 Tablet should be taken with or after food.

- Alcohol : CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with ADMINE 400 Tablet. Please consult your doctor. | - Pregnancy : UNSAFE

ADMINE 400 Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant. | - Breast feeding : UNSAFE

ADMINE 400 Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby. | - Driving : UNSAFE

ADMINE 400 Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur. | - Kidney : CAUTION

ADMINE 400 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed. | - Liver : CAUTION

ADMINE 400 Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

If you miss a dose of ADMINE 400 Tablet, skip it and continue with your normal schedule. Do not double the dose.

Can ADMINE 400 Tablet be taken with food?::: Yes, the best way to take it is with a glass of water and food. This prevents irritation in the food pipe and stomach. If you cannot swallow it, put the tablets in a glass of water or apple juice (approximately 50 ml for a 100 mg tablet and 200 ml for a 400 mg tablet). Stir it with a spoon to make it uniform and drink it immediately.| Is it safe to drive while taking ADMINE 400 Tablet?::: ADMINE 400 Tablet may cause dizziness, lightheadedness or drowsiness in some people. Make sure you know how you react to it before you drive a car or operate machinery.| What precautions need to be followed while taking ADMINE 400 Tablet?::: While taking ADMINE 400 Tablet, make sure you follow all the instructions given by your doctor, carefully and keep all appointments. You will need regular follow-up to ensure that the treatment is working. Regular blood tests, weight checks, and urine tests may be required to find out any side effects before it becomes serious. Make sure you use a method of contraception to prevent pregnancy during treatment with ADMINE 400 Tablet. Tell your doctor immediately if you become pregnant while you are taking this medicine. If you are about to start taking any new medicine, remind your doctor that you are taking ADMINE 400 Tablet.| Ever since I started using ADMINE 400 Tablet, I have noticed that I develop rashes and severe itching when I have sun exposure. Is it because of the medicine or the disease?::: This medicine may make your skin much more sensitive to sunlight than it normally is. Exposure to sunlight may cause skin rash, itching, redness or severe sunburn. When you are outdoors, wear protective clothing and use a sunscreen with an SPF of 15 or higher. If you feel a burning sensation on your skin, tell your doctor.| The doctor has advised me not to take any medicine on my own while taking ADMINE 400 Tablet. Should I consult my doctor even if I need to take paracetamol for my fever?::: Yes, there are a number of medicines which interfere with ADMINE 400 Tablet, including paracetamol. Therefore you should not self medicate while taking ADMINE 400 Tablet. Other medicines which interfere with ADMINE 400 Tablet include cyclosporin, dexamethasone (a steroid), warfarin, antiviral medicines which treat AIDS and some medicines which treat bacterial infections, high cholesterol, high blood pressure, heart problems, and mental disorders and depression. Consult your doctor before taking any medicine, and inform him that you are on ADMINE 400 Tablet therapy.| Can I expect that if I take ADMINE 400 Tablet regularly and as advised by the doctor for CML, I will be cured?::: ADMINE 400 Tablet has proved effective in many cases of CML. It is also noticed that the chances of survival increase after taking this medicine. The doctor who is treating CML can tell you better. The doctor will analyze your current state, blood test results, response to treatment, any other medical illness which you may be having, etc. and tell you.

ADMINE 400 Tablet is an anti-cancer medication. A protein enzyme, bcr-abl tyrosine kinase, responsible for the growth of abnormal proliferation of cancer cells. This medicine inhibits the proliferation and induces apoptosis (planned cell death) in bcr-abl positive cells (cancer cells). This is how it works to stop or slow the spread of cancer.

-Atorvastatin (Oral Route): Severe

Do not consume Atorvastatin with Imatinib mesylate. If concurrent use is essential, watch out for symptoms such as unexplained muscle pain, tenderness or weakness and consult your doctor if you experience them. They may adjust the dose of Atorvastatin accordingly. Imatinib mesylate may raise blood levels of Atorvastatin.Concurrent use may cause muscle damage.

| -Ranolazine (Oral Route): Severe

Watch out for symptoms of Imatinib mesylate side effects such as nausea, vomiting, headache, dizziness, constipation or weakness and consult your doctor if you experience them. They may adjust the dose of Imatinib mesylate accordingly. Imatinib mesylate may raise blood levels of Ranolazine.Concurrent use may cause life-threatening disturbances in the heart rhythm.

| -Pimozide (Oral Route): Severe

Do not consume Pimozide with Imatinib mesylate. Concomitant use may affect heart rhythm and can be fatal.

| -Vinblastine (Injection Route): Severe

Concomitant use is not recommended. Please consult with your doctor. Imatinib mesylate may raise blood levels of Vinblastine.Concurrent use may cause hairloss, drop in blood cell counts, and nervous system disorders.

| -Vincristine (Injection Route): Severe

Concomitant use is not recommended. Please consult with your doctor. Imatinib mesylate may raise blood levels of Vincristine.Concurrent use may cause hairloss, drop in blood cell counts, and nervous system disorders.

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