Take this medicine in the dose and duration as advised by your doctor. Adcilib Capsule should be taken with or after food.

- Alcohol : CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Adcilib Capsule. Please consult your doctor. | - Pregnancy : CONSULT YOUR DOCTOR

Adcilib Capsule is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks. | - Breast feeding : UNSAFE

Adcilib Capsule is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby. | - Driving : UNSAFE

Adcilib Capsule may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.It may cause fatigue in some people. If this happens, you should exercise caution when driving or using machines. | - Kidney : CAUTION

Adcilib Capsule should be used with caution in patients with severe kidney disease. Dose adjustment may be needed. | - Liver : CAUTION

Adcilib Capsule should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

If you miss a dose of Adcilib Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

What kind of medicine is Adcilib Capsule?::: Adcilib Capsule is an anti-cancer medicine. Adcilib Capsule blocks proteins known as cyclin-dependent kinase inhibitors. Blocking these proteins can slow down the growth of cancer cells and delay the progression of the cancer.| How long do I have to take Adcilib Capsule?::: The duration of treatment varies from person to person. Your doctor will decide the number of cycles you need to receive based on your condition, response to treatment and your tolerance to side effects. Your doctor may decrease your dose or stop your treatment temporarily or permanently if you experience certain side effects.| Are the side effects of Adcilib Capsule irreversible?::: No, most of the side effects are reversible and disappear when the medicine is stopped. Neutropenia is a well-recognized adverse effect of Adcilib Capsule in which the number of your white blood cells get reduced and your immune system gets weakened. As a result, you may be at greater risk of getting an infection while you are taking Adcilib Capsule. However, this side effect disappears rapidly once you stop taking the medicine.| Does treatment with Adcilib Capsule require monitoring of blood counts?::: Yes, blood tests are important since this medicine can lower your blood counts. The regular blood tests check the effect of Adcilib Capsule on your blood cells (white blood cells, red blood cells, and platelets). These tests should be done at the beginning of each chemotherapy cycle, on the 15th day of the first 2 cycles, and as clinically indicated.| How should I take Adcilib Capsule?::: Generally, Adcilib Capsule is taken once daily for 21 consecutive days followed by 7 days off treatment to add up a complete cycle of 28 days. Take this medicine with food and at the same time each day. Swallow the whole capsules. Do not open, chew, or crush them. Do not take the capsules that are broken or cracked. If you vomit after taking Adcilib Capsule, do not take another dose and continue your regular dosing schedule.| Do I need to use birth control method while using Adcilib Capsule?::: Women of childbearing potential who are receiving Adcilib Capsule and their partners should use adequate contraceptive methods (e.g. double-barrier contraception such as condom and diaphragm). These methods should be used during therapy and for at least 3 weeks after completing therapy for females. Men who are on Adcilib Capsule therapy should use birth control methods for at least 14 weeks after completing the therapy.| Does Adcilib Capsule affect fertility?::: Male fertility may be affected during treatment with Adcilib Capsule. Thus, men may consider sperm preservation prior to beginning therapy with Adcilib Capsule.| What are the serious side effects of Adcilib Capsule?::: The serious side effects of Adcilib Capsule include shortness of breath, dizziness, weakness, unusual bleeding or bruising or nosebleeds. It may also cause fever, chills or signs of infection and fast, irregular or pounding heartbeat. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment.

Adcilib Capsule is an anti-cancer medication. Cyclin dependent kinase 4 and 6\n(chemical messengers) are downstream of signaling pathways which lead to the proliferation of cells. This medicine works by inhibiting cyclin dependent kinase 4 and 6, thus arrests the cancer cell cycle (cell growing process). It also targets the estrogen (hormone) receptor-positive breast cancer cells by disrupting the cell cycle.

-Carbamazepine (Oral Route): Severe

Do not consume Palbociclib with Carbamazepine. Carbamazepine may reduce blood levels of Palbociclib.

| -Enzalutamide (Oral Route): Severe

Do not consume Palbociclib with Enzalutamide. Enzalutamide may reduce blood levels of Palbociclib.

| -Fosphenytoin (Injection Route): Severe

Do not consume Palbociclib with Fosphenytoin. Fosphenytoin may reduce blood levels of Palbociclib.

| -Phenobarbitone (Oral Route): Severe

Do not consume Palbociclib with Phenobarbitone. Phenobarbitone may reduce blood levels of Palbociclib.

| -Phenobarbitone (Injection Route): Severe

Do not consume Palbociclib with Phenobarbitone. Phenobarbitone may reduce blood levels of Palbociclib.

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