Do not drink alcohol while you are taking this medicine. Acupain 50mg Capsule may cause excessive drowsiness when taken with alcohol. | - Pregnancy : CONSULT YOUR DOCTOR

Acupain 50mg Capsule is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks. | - Breast feeding : UNSAFE

Acupain 50mg Capsule is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.Consult a doctor immediately if the baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing problems, or limpness. | - Driving : UNSAFE

Acupain 50mg Capsule may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.Acupain 50mg Capsule may cause side effects such as drowsiness and blurred vision. If this happens, do not drive. | - Kidney : CAUTION

Acupain 50mg Capsule should be used with caution in patients with severe kidney disease. Dose adjustment may be needed. | - Liver : CAUTION

Acupain 50mg Capsule should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Do not consume Selegiline with Tramadol. If essential, watch out for symptoms such as fever, tremors, diarrhea or agitation. Please consult your doctor. Concomitant use may cause an increase in blood serotonin levels. Patients may experience agitation, increased body temperature, fast heartbeat, muscle rigidity, and loss of coordination.

| -Naltrexone (Oral Route): Life-threatening

Do not consume Naltrexone with Tramadol; watch out for symptoms such as breathlessness, increased heart rate, or headache. Naltrexone may reduce efficacy of Tramadol.

| -Tranylcypromine (Oral Route): Life-threatening

Do not consume Tranylcypromine with Tramadol. If Tranylcypromine is essential, ensure a gap of At least 2 weeks between taking Tranylcypromine and Tramadol. Please consult your doctor. Concomitant use may cause an increase in blood serotonin levels. Patients may experience agitation, increased body temperature, fast heartbeat, muscle rigidity, and loss of coordination.

| -Moclobemide (Oral Route): Severe

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Concurrent use may cause serotonin syndrome.

| -Alprazolam (Oral Route): Severe

If concurrent use is essential, watch out for symptoms of Alprazolam side effects such as drowsiness, excessive sedation, tiredness, dizziness or slurred speech and consult your doctor if you experience them. They may adjust the dose of Alprazolam as per the observations. It is advised to avoid driving or undertaking other tasks requiring skill and alertness. Concurrent use may cause increased sleepliness, slow breathing, and even death.